Early Human Milk Fortification in Infants Born Extremely Preterm: A Randomized Trial.

ABSTRACT:

Objectives

Enteral nutrition with unfortified human milk during the first 2 postnatal weeks often leads to cumulative protein and energy deficits among preterm infants. Fortified human milk administered soon after birth could increase fat-free mass (FFM) and improve growth in these infants.

Methods

This was a masked, randomized trial. Starting on feeding day 2, extremely preterm infants 28 weeks or younger fed maternal or donor milk were randomized to receive either a diet fortified with a human-based product (intervention group) or a standard, unfortified diet (control group). This practice continued until the feeding day when a standard bovine-based fortifier was ordered. Caregivers were masked. The primary outcome was FFM-for-age z score at 36 weeks of postmenstrual age (

SUBMITTER: Salas AA 

PROVIDER: S-EPMC10471508 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature