Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives.

ABSTRACT: Advancements in understanding the pathogenesis mechanisms underlying gastrointestinal diseases, encompassing inflammatory bowel disease, gastrointestinal cancer, and gastroesophageal reflux disease, have led to the identification of numerous novel therapeutic targets. These discoveries have opened up exciting possibilities for developing gene therapy strategies to treat gastrointestinal diseases. These strategies include gene replacement, gene enhancement, gene overexpression, gene function blocking, and transgenic somatic cell transplantation. In this review, we introduce the important gene therapy targets and targeted delivery systems within the field of gastroenterology. Furthermore, we provide a comprehensive overview of recent progress in gene therapy related to gastrointestinal disor

SUBMITTER: Yue NN 

PROVIDER: S-EPMC10471515 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature