In silico guided screening of active components of <i>C. lanceolata</i> as 3-chymotrypsin-like protease inhibitors of novel coronavirus.

ABSTRACT: Despite the intense worldwide efforts towards the identification of potential anti-CoV therapeutics, no antiviral drugs have yet been discovered. Numerous vaccines are now approved for use, but they all serve as preventative measures. To effectively treat viral infections, it is crucial to find new antiviral drugs that are derived from natural sources. Various compounds with potential activity against 3 chymotrypsin-like protease (3CLpro) were reported and some are validated by bioassay studies. Therefore, we performed the computational screening of phytoconstituents of Codonopsis lanceolata to search for potential antiviral hit candidates. The curated compounds of the plant C. lanceolata were collected and downloaded from the literature. The binding affinity of the curated d

SUBMITTER: Sharma G 

PROVIDER: S-EPMC10471561 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature