Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome.

ABSTRACT: Oral microbiome is the second largest microbial community in humans after gut. Human immunodeficiency virus (HIV) infection triggers an impairment of the immune system which could favour the growth and the colonization of pathogens in the oral cavity, and this dysbiosis has been associated with oral manifestations that worsen the quality of life of these patients. Antiretroviral therapy (ART) could also drive changes in specific oral bacterial taxa associated with such periodontal diseases. Integrase strand transfer inhibitors (INSTIs), therapy of choice in the treatment of naive HIV-patients, are able to reverse the impact of HIV infection on systemic inflammation, gut permeability, and gut bacterial diversity/richness. The objective of this study was to analyse the effects of HIV infecti

SUBMITTER: Villoslada-Blanco P 

PROVIDER: S-EPMC10471600 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature