Functional annotation and comparative genomics analysis of Balamuthia mandrillaris reveals potential virulence-related genes.

ABSTRACT: Balamuthia mandrillaris is a pathogenic protozoan that causes a rare but almost always fatal infection of the central nervous system and, in some cases, cutaneous lesions. Currently, the genomic data for this free-living amoeba include the description of several complete mitochondrial genomes. In contrast, two complete genomes with draft quality are available in GenBank, but none of these have a functional annotation. In the present study, the complete genome of B. mandrillaris isolated from a freshwater artificial lagoon was sequenced and assembled, obtaining an assembled genome with better assembly quality parameter values than the currently available genomes. Afterward, the genome mentioned earlier, along with strains V039 and 2046, were subjected to functional annotation. Finally, comp

SUBMITTER: Otero-Ruiz A 

PROVIDER: S-EPMC10471605 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature