Leading basic modes of spontaneous activity drive individual functional connectivity organization in the resting human brain.

ABSTRACT: Spontaneous activity of the human brain provides a window to explore intrinsic principles of functional organization. However, most studies have focused on interregional functional connectivity. The principles underlying rich repertoires of instantaneous activity remain largely unknown. We apply a recently proposed eigen-microstate analysis to three resting-state functional MRI datasets to identify basic modes that represent fundamental activity patterns that coexist over time. We identify five leading basic modes that dominate activity fluctuations. Each mode exhibits a distinct functional system-dependent coactivation pattern and corresponds to specific cognitive profiles. In particular, the spatial pattern of the first leading basis mode shows the separation of activity between the defa

SUBMITTER: Chen X 

PROVIDER: S-EPMC10471630 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature