Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study.

ABSTRACT:

Rationale

Alcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder (AUD). While medication effects on the primary outcomes for these paradigms are assumed to be qualitatively related, there is a critical lack of quantitative evidence to support this hypothesis.

Objectives

The study aims to test the relationship between medication effect sizes on subjective response to alcohol administration and medication effect sizes for cue-induced craving to cue exposure, using meta-analysis.

Methods

Systematic literature searches were conducted to identify randomized trials, wherein AUD medications were tested using the alcohol administration and/or cue-reactivity paradigms. From these studie

SUBMITTER: Ray LA 

PROVIDER: S-EPMC10471658 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature