Sex differences in acute delta-9-tetrahydrocannabinol (Δ⁹-THC) response and tolerance as a function of mouse strain.

ABSTRACT: Cannabinoids are increasingly used to alleviate pain; however, tolerance to their antinociceptive effects, including those of delta-9-tetrahydrocannabinol (Δ⁹-THC), may limit their therapeutic utility. With more women than men using medical cannabis for pain relief, it is crucial to understand how sex influences cannabinoid-mediated antinociception and tolerance. Though studies in rats consistently find females are more sensitive to the acute antinociceptive effects of cannabinoids, our work with mice consistently finds the converse. The present study examined whether our observed sex differences in Δ⁹-THC-induced antinociception and tolerance are consistent across multiple mouse strains or are strain-dependent. Male and female C57BL/6J (B6), DBA/2, AKR, and CBA/J mic

SUBMITTER: Lulek CF 

PROVIDER: S-EPMC10471687 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature