Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs.

ABSTRACT:

Rationale

Rodent vendors are often utilized interchangeably, assuming that the phenotype of a given strain remains standardized between colonies. Several studies, however, have found significant behavioral and physiological differences between Sprague Dawley (SD) rats from separate vendors. Prepulse inhibition of startle (PPI), a form of sensorimotor gating in which a low-intensity leading stimulus reduces the startle response to a subsequent stimulus, may also vary by vendor. Differences in PPI between rat strains are well known, but divergence between colonies within the SD strain lacks thorough examination.

Objectives

We explored intrastrain variation in PPI by testing SD rats from two vendors: Envigo and Charles River (CR).

Methods

We selected drugs acting on four

SUBMITTER: Caine SB 

PROVIDER: S-EPMC10471717 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature