Injectable, pore-forming, self-healing, and adhesive hyaluronan hydrogels for soft tissue engineering applications.

ABSTRACT: Most existing injectable hydrogels are non-porous, thereby lacking a microporous structure to promote cell ingrowth. Also, most hydrogels do not effectively adhere to the host tissue. The present study describes an injectable double network hydrogel formed by combining two hyaluronic acid (HA) derivatives, namely dopamine grafted HA (DAHA) and methacrylated HA (HAMA). These constituents instantly form a physically crosslinked network through Fe³⁺-dopamine coordination, and confer fast gelation, pore formation, and self-healing properties to the hydrogel. Photocroslinked upon UV exposure, HAMA forms a chemically crosslinked network, thereby improving mechanical and degradation properties. The adhesive properties of this hydrogel are attributed to the presence of dopamine groups,

SUBMITTER: Nejati S 

PROVIDER: S-EPMC10471737 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature