A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells.

ABSTRACT: Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy Factor 1 (NAF-1; NAF-1^44-67), selectively permeates and kills human metastatic epithelial breast cancer cells (MDA-MB-231), but not control epithelial cells. As cancer cells alter their phenotype during growth and metastasis, we tested whether NAF-1^44-67 would also be efficient in killing other human epithelial breast cancer cells that may have a different phenotype. Here we report that NAF-1^44-67 is efficient in killing BT-549, Hs 578T, MDA-MB-436, and MDA-MB-453 breast cancer cells, but that MDA-MB-157 cells are resistant to it. Upon closer examinat

SUBMITTER: Rowland L 

PROVIDER: S-EPMC10471752 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature