Tranexamic acid for the prevention of postpartum bleeding in women with anaemia:  Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial.

ABSTRACT: Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown of fibrin blood clots. TXA decreases surgical bleeding and reduces deaths from bleeding after traumatic injury. When given within three hours of birth, TXA reduces deaths from bleeding in women with PPH. However, for many women, treatment of PPH is too late to prevent death. World-wide, over one-third of pregnant women are anaemic and many are severely anaemic. These women have an increased risk of PPH and are more likely to die if PPH occurs. There is an urgent need to identify ways to prevent severe postpartum bleeding in anaemic women. The WOMAN

SUBMITTER: Collier T 

PROVIDER: S-EPMC10471795 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature