Creatine supplementation enhances anti-tumor immunity by promoting adenosine triphosphate production in macrophages.

ABSTRACT: Creatine is an indispensable organic compound utilized in physiological environments; however, its role in immunity is still poorly understood. Here, we show that creatine supplementation enhances anti-tumor immunity through the functional upregulation of macrophages by increasing adenosine triphosphate (ATP) production. Creatine supplementation significantly suppressed B16-F10-originated tumor growth in mice compared with the control treatment. Under these conditions, intratumor macrophages polarized towards the M1 phenotype rather than the M2 phenotype, and there was an increase in tumor antigen-specific CD8+ T cells in the mice. The cytokine production and antigen-presenting activity in the macrophages were enhanced by creatine supplementation, resulting in a substantial increase in tum

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10471797 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature