Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus.

ABSTRACT: The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash, generally self-limiting, although patients may develop a chronic disabling condition or suffer lethal complications. Unfortunately, there is no specific treatment or vaccine available. Thus, the search for effective therapies to control CHIKV infection is an urgent need. This study evaluated the antiviral activity of flavonoids isolated from Marcetia taxifolia by in vitro and in silico analysis. Cytotoxicity of compounds was determined by MTT assay and viral load was assessed in cell substrates supernatants by plaque-forming and RT-qPCR assays. Selected molecules were analyzed by molecular doc

SUBMITTER: Munoz AL 

PROVIDER: S-EPMC10471840 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature