Dataset Information

Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study.

ABSTRACT:

Objective

The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.

Design

Repeated cross-sectional population-based studies.

Setting

The two Northern counties (Norr- and Västerbotten) in Sweden.

Participants

Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).

Interventions

None.

Measures

Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR_crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR_cysC). Renal function over time was analysed using univariable and multivariable linear regression models.

Results

Renal function, both eGFR_crea and eGFR_cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR_crea and eGFR_cysC (both p<0.001) after adjustment for classical cardiovascular RF.

Conclusion

Renal function has deteriorated in Northern Sweden between 1986 and 2014.

SUBMITTER: de Man Lapidoth J

PROVIDER: S-EPMC10471859 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study.

de Man Lapidoth Julia J Hultdin Johan J Jonsson P Andreas PA Eriksson Svensson Maria M Wennberg Maria M Zeller Tanja T Söderberg Stefan S

BMJ open 20230830 8

<h4>Objective</h4>The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.<h4>Design</h4>Repeated cross-sectional population-based studies.<h4>Setting</h4>The two Northern counties (Norr- and Väster ...[more]

PMID: 37648389

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Dataset Information

Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study.

Objective

Design

Setting

Participants

Interventions

Measures

Results

Conclusion

Publications

Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study.

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