Ancestral diversity in lipoprotein(a) studies helps address evidence gaps.

ABSTRACT:

Introduction

The independent and causal cardiovascular disease risk factor lipoprotein(a) (Lp(a)) is elevated in >1.5 billion individuals worldwide, but studies have prioritised European populations.

Methods

Here, we examined how ancestrally diverse studies could clarify Lp(a)'s genetic architecture, inform efforts examining application of Lp(a) polygenic risk scores (PRS), enable causal inference and identify unexpected Lp(a) phenotypic effects using data from African (n=25 208), East Asian (n=2895), European (n=362 558), South Asian (n=8192) and Hispanic/Latino (n=8946) populations.

Results

Fourteen genome-wide significant loci with numerous population specific signals of large effect were identified that enabled construction of Lp(a) PRS of moderate (R²=

SUBMITTER: Lee MP 

PROVIDER: S-EPMC10471864 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature