Ferroptosis and its potential role in gestational diabetes mellitus: updated evidence from pathogenesis to therapy.

ABSTRACT:

Background

Studies have demonstrated that high iron status is positively associated with gestational diabetes mellitus (GDM), implying that iron overload and ferroptosis play important roles in the development of GDM. The aim of this study was to explore effective therapeutic drugs from traditional Chinese medicine (TCM)formulas for the treatment of GDM based on ferroptosis.

Methods

In this study, the presence of ferroptosis in the placenta was verified through clinical and experimental data, and key genes were subsequently screened for association with ferroptosis in the development of GDM. The analysis was based on transcriptome sequencing of datasets combined with differentially expressed genes (DEGs) analysis and weighted gene correlation network analysis (WGCNA); functi

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10471987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature