Identification of cancer stemness and M2 macrophage-associated biomarkers in lung adenocarcinoma.

ABSTRACT:

Objective

Cancer stemness and M2 macrophages are intimately linked to the prognosis of lung adenocarcinoma (LUAD). For this reason, this investigation sought to identify the key genes relevant to cancer stemness and M2 macrophages, explore the relationship between these genes and clinical characteristics, and determine the potential mechanism.

Methods

LUAD transcriptomic data was analyzed from The Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus databases. Differential expression analysis was performed to discern abnormally expressed genes between LUAD and control samples in TCGA cohort. The Cell type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) algorithm was applied to determine varyingly infiltrated immune cells in LUAD comp

SUBMITTER: Wang X 

PROVIDER: S-EPMC10472008 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature