Effect of obesity, lipids and adipokines on allergic rhinitis risk: a Mendelian randomization study.

ABSTRACT:

Objectives

Observational studies suggested that obesity may promote the development of allergic rhinitis. The aim of this study was to explore the association of obesity, lipids and adipokines with this allergic disease at the genetic level using Mendelian randomization strategies.

Methods

Summary data for three obesity indicators (such as body mass index), eight lipid indicators (such as triglycerides) and six adipokines (such as interleukin-6 and adipocyte fatty acid-binding protein) were collected, and suitable instrumental variables were extracted from these summary data according to the three main assumptions of Mendelian randomization. Three Mendelian randomization methods (such as inverse variance weighted) were used to detect the casual effect of the above indicators

SUBMITTER: Lin C 

PROVIDER: S-EPMC10472243 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature