Integration of operator-validated contours in deformable image registration for dose accumulation in radiotherapy.

ABSTRACT:

Background and purpose

Deformable image registration (DIR) is a core element of adaptive radiotherapy workflows, integrating daily contour propagation and/or dose accumulation in their design. Propagated contours are usually manually validated and may be edited, thereby locally invalidating the registration result. This means the registration cannot be used for dose accumulation. In this study we proposed and evaluated a novel multi-modal DIR algorithm that incorporated contour information to guide the registration. This integrates operator-validated contours with the estimated deformation vector field and warped dose.

Materials and methods

The proposed algorithm consisted of both a normalized gradient field-based data-fidelity term on the images and an optical flow data-fid

SUBMITTER: Bosma LS 

PROVIDER: S-EPMC10472292 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature