Management Paradigm of Central Nervous System Metastases in NSCLC: An Australian Perspective.

ABSTRACT: Life-prolonging central nervous system active systemic therapies for metastatic NSCLC have increased the complexity of managing brain metastases (BMs). Australian medical oncologists, radiation oncologists, and neurosurgeons discussed the evidence guiding the diverse clinical approaches to the management of BM in NSCLC. The Australian context is broadly applicable to other jurisdictions; therefore, we have documented these discussions as principles with broader applications. Patient management was stratified according to clinical and radiologic factors under two broad classifications of newly diagnosed BMs: symptomatic and asymptomatic. Other important considerations include the number and location of metastases, tumor histotypes, molecular subtype, and treatment purpose. Careful considera

SUBMITTER: Lee CK 

PROVIDER: S-EPMC10472312 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature