Ictal vocalizations in the Scn1a^+/- mouse model of Dravet syndrome.

ABSTRACT:

Objective

Ictal vocalizations have shown diagnostic utility in epilepsy patients. Audio recordings of seizures have also been used for seizure detection. The present study aimed to determine whether generalized tonic-clonic seizures in the Scn1a^+/- mouse model of Dravet syndrome are associated with either audible mouse squeaks or ultrasonic vocalizations.

Methods

Acoustic recordings were captured from group-housed Scn1a^+/- mice undergoing video-monitoring to quantify spontaneous seizure frequency. We generated audio clips (n = 129) during a generalized tonic-clonic seizure (GTCS) that included 30 seconds immediately prior to the GTCS (preictal) and 30 seconds following the conclusion of the seizure (postictal). Nonseizure clips (n = 129) were also expor

SUBMITTER: Anderson LL 

PROVIDER: S-EPMC10472354 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature