Dataset Information

Usefulness of the cachexia index as a prognostic indicator for patients with gastric cancer

ABSTRACT: Abstract

Aim

Cachexia is associated with the morbidity and mortality of cancer patients. The cachexia index (CXI) is a novel biomarker of cachexia associated with the prognosis for certain cancers. This study analyzed the relationship between CXI with long‐term outcomes of gastric cancer patients.

Methods

We included 175 gastric cancer patients who underwent curative gastrectomy at our hospital between January 2011 and October 2019. The CXI was calculated using skeletal muscle index, serum albumin level, and neutrophil‐to‐lymphocyte ratio. The prognostic value of CXI was investigated by univariate and multivariate Cox hazard regression models adjusting for potential confounders.

Results

In the multivariate analyses, tumor location (hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.11–0.49; p < 0.01), disease stage (HR, 15.4; 95% CI, 4.18–56.1; p < 0.01), and low CXI (HR, 2.97; 95% CI, 1.01–8.15; p = 0.03) were independent and significant predictors of disease‐free survival. Disease stage (HR, 9.88; 95% CI, 3.53–29.1; p < 0.01) and low CXI (HR, 4.07; 95% CI, 1.35–12.3; p < 0.01) were independent and significant predictors of overall survival. The low CXI group had a lower body mass index (p = 0.02), advanced disease stage (p = 0.034), and a lower prognostic nutritional index (p < 0.01).

Conclusions

Cachexia index is associated with a poor prognosis for gastric cancer, suggesting the utility of comprehensive assessment using nutritional, physical, and inflammatory status. Cachexia index, a recently defined parameter can be a prognostic predictor for gastric cancer patients. Our results suggest that inflammatory status and muscle mass are associated with tumor recurrence and progression in gastric cancer.

SUBMITTER: Nakashima K

PROVIDER: S-EPMC10472360 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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