Drugs acting at TRPM7 channels inhibit seizure-like activity.
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ABSTRACT:
SUBMITTER: Khalil A
PROVIDER: S-EPMC10472385 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Drugs acting at TRPM7 channels inhibit seizure-like activity.
Khalil Aytakin A Shekh-Ahmad Tawfeeq T Kovac Stjepana S Wykes Robert C RC Horgen F David FD Fleig Andrea A Walker Matthew C MC
Epilepsia open 20230620 3
Transient receptor potential cation subfamily M7 (TRPM7) channels are ion channels permeable to divalent cations. They are abundantly expressed with particularly high expression in the brain. Previous studies have highlighted the importance of TRPM7 channels in brain diseases such as stroke and traumatic brain injury, yet evidence for a role in seizures and epilepsy is lacking. Here, we show that carvacrol, a food additive that inhibits TRPM7 channels, and waixenicin A, a novel selective and pot ...[more]
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