Primary tumour category, site of metastasis, and baseline serum S100B and LDH are independent prognostic factors for survival in metastatic melanoma patients treated with anti-PD-1.

ABSTRACT:

Background

Prognostic classification of metastatic melanoma patients treated with anti-PD-1 is of great interest to clinicians.

Objective

We aimed to determine the anti-PD-1 treatment related prognostic performance of demographics, clinical and histological prognostic markers and baseline serum S100B and LDH levels in advanced melanoma.

Methods

A total of 200 patients with unresectable metastatic melanoma were included in this retrospective study. 34.5% had stage M1c disease and 11.5% had stage M1d disease at the start of therapy. 30% had pT4b primary melanoma. 55.5% had elevated baseline serum S100B levels and 62.5% had elevated baseline serum LDH levels. We analysed the risk of death using univariate and multivariate Cox proportional-hazards models and the median ov

SUBMITTER: Janka EA 

PROVIDER: S-EPMC10472446 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature