No causal association between plasma cystatin C and cardiovascular diseases: Mendelian randomization analyses in UK biobank

ABSTRACT:

Background

We aimed to determine whether the plasma cystatin C is a causal risk factor for cardiovascular events, stroke, myocardial infarction (MI), and cardiovascular disease (CVD) mortality by conducting Mendelian randomization (MR) designs.

Methods

Our study included 277,057 individuals free of CVDs or cancer at baseline in the UK Biobank. The genetic scores of plasma cystatin C comprising 67 single-nucleotide polymorphisms were calculated on the basis of data from a large genome-wide association study. By stratifying the genetic score, we conducted cox regression to assess the relationship between plasma cystatin C and CVDs. In this study, linear MR analysis was used to estimate the causal association between plasma cystatin C and CVDs.

Results

Observational

SUBMITTER: Tu J 

PROVIDER: S-EPMC10472449 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature