DNA methylation patterns in CD4⁺ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis.

ABSTRACT:

Background

Psoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients. Although joint disease typically follows the onset of skin psoriasis, in around 15% of cases it is the initial presentation, which can result in diagnostic delays. The pathophysiological mechanisms underlying psoriasis and PsA are not yet fully understood, but there is evidence pointing towards epigenetic dysregulation involving CD4⁺ and CD8⁺ T-cells.

Objectives

The aim of this study was to investigate disease-associated DNA methylation patterns in CD4⁺ T-cells from psoriasis and PsA patients that may represent potential diagno

SUBMITTER: Natoli V 

PROVIDER: S-EPMC10472451 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature