Comparison of Different Modeling Approaches for Prescription Opioid Use and Its Association With Adverse Events.

ABSTRACT: Previous research linking opioid prescribing to adverse drug events has failed to properly account for the time-varying nature of opioid exposure. This study aimed to explore how the risk of opioid-related emergency department visits, readmissions, or deaths (composite outcome) varies with opioid dose and duration, comparing different novel modeling techniques. A prospective cohort of 1,511 hospitalized patients discharged from 2 McGill-affiliated hospitals in Montreal, 2014-2016, was followed from the first postdischarge opioid dispensation until 1 year after discharge. Marginal structural Cox proportional hazards models and their flexible extensions were used to explore the association between time-varying opioid use and the composite outcome. Weighted cumulative exposure models assessed

SUBMITTER: Kurteva S 

PROVIDER: S-EPMC10472496 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature