Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.

ABSTRACT: Theories of consciousness suggest that brain mechanisms underlying transitions into and out of unconsciousness are conserved no matter the context or precipitating conditions. We compared signatures of these mechanisms using intracranial electroencephalography in neurosurgical patients during propofol anesthesia and overnight sleep and found strikingly similar reorganization of human cortical networks. We computed the "effective dimensionality" of the normalized resting state functional connectivity matrix to quantify network complexity. Effective dimensionality decreased during stages of reduced consciousness (anesthesia unresponsiveness, N2 and N3 sleep). These changes were not region-specific, suggesting global network reorganization. When connectivity data were embedded into a low-dime

SUBMITTER: Krause BM 

PROVIDER: S-EPMC10472497 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature