Single-cell profiling reveals various types of interstitial cells in the bladder.

ABSTRACT: Clarifying the locations, molecular markers, functions and roles of bladder interstitial cells is crucial for comprehending the pathophysiology of the bladder. This research utilized human, rat and mouse bladder single-cell sequencing, bioinformatics analysis and experimental validation. The main cell types found in human, rat and mouse bladder tissues include epithelial cells, smooth muscle cells, endothelial cells, fibroblasts, myofibroblasts, neurons and various immune cells. Our study identified two significant types of interstitial cells (PTN⁺ IGFBP6⁺ PI16 (CD364)⁺ CD34⁺ ) and myofibroblasts (STC1⁺ PLAT⁺ TNC⁺ ). These two types of interstitial cells are mainly located in the subepithelial lamina propria, betw

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10472517 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature