Association between circadian physical activity patterns and mortality in the UK Biobank.

ABSTRACT:

Background

The benefit of physical activity (PA) for increasing longevity is well-established, however, the impact of diurnal timing of PA on mortality remains poorly understood. We aimed to derive circadian PA patterns and investigate their associations with all-cause mortality.

Methods

We used 24 h PA time series from 96,351 UK Biobank participants aged between 42 and 79 years at accelerometry in 2013-2015. Functional principal component analysis (fPCA) was applied to obtain circadian PA patterns. Using multivariable Cox proportional hazard models, we related the loading scores of these fPCs to estimate risk of mortality.

Results

During 6.9 years of follow-up, 2,850 deaths occurred. Four distinct fPCs accounted for 96% of the variation of the accelerometry data. Usi

SUBMITTER: Stein MJ 

PROVIDER: S-EPMC10472628 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature