A highly sensitive and green electroanalytical method for the determination of favipiravir in pharmaceutical and biological fluids.

ABSTRACT:

Background

Favipiravir is currently used for the treatment of coronavirus disease-2019 (COVID-19).

Objective

A highly sensitive and eco-friendly electroanalytical method was developed to quantify favipiravir.

Method

The voltammetric method optimized a sensor composed of reduced graphene oxide / modified carbon paste electrode in the presence of an anionic surfactant, improving the favipiravir detection limit. The investigation reveals that favipiravir-oxidation is a diffusion-controlled irreversible process. The effects of various pH and scan rates on oxidation anodic peak current were investigated.

Results

The developed method offers a wide linear dynamic range of 1.5-420 ng/mL alongside a higher sensitivity with a limit of detection in the nanogram range (0.4

SUBMITTER: El-Sayed HM 

PROVIDER: S-EPMC10472665 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature