Brain tissue oxygen monitoring in traumatic brain injury: part I-To what extent does PbtO₂ reflect global cerebral physiology?

ABSTRACT:

Background

The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviation from the PRx-based optimal CPP value (∆CPPopt; actual CPP-CPPopt) in relation to brain tissue oxygenation (pbtO₂) in traumatic brain injury (TBI).

Methods

A total of 425 TBI patients with ICP- and pbtO₂ monitoring for at least 12 h, who had been treated at the neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, between 2002 and 2022 were included. Generalized additive models (GAMs) and linear mixed effect models were used to explore the association of ICP, PRx, CPP, and CPPopt in relation to pbtO₂. PbtO₂

SUBMITTER: Svedung Wettervik T 

PROVIDER: S-EPMC10472704 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature