Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study.

ABSTRACT:

Background

Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction.

Methods

We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and ter

SUBMITTER: Mizuno S 

PROVIDER: S-EPMC10472725 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature