K_Ca-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic Indications.

ABSTRACT: Although potassium channelopathies have been linked to a wide range of neurological conditions, the underlying pathogenic mechanism is not always clear, and a systematic summary of clinical manifestation is absent. Several neurological disorders have been associated with alterations of calcium-activated potassium channels (K_Ca channels), such as loss- or gain-of-function mutations, post-transcriptional modification, etc. Here, we outlined the current understanding of the molecular and cellular properties of three subtypes of K_Ca channels, including big conductance K_Ca channels (BK), small conductance K_Ca channels (SK), and the intermediate conductance K_Ca channels (IK). Next, we comprehensively reviewed the loss- or gain-of-function mu

SUBMITTER: Zahra A 

PROVIDER: S-EPMC10472807 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature