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TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

ABSTRACT:

Abbreviations

Aβ: amyloid β; AD: Alzheimer disease; AMPK: 5' adenosine monophosphate-activated protein kinase; CTSB: cathepsin B; CTSD: cathepsin D; DM: diabetes mellitus; ESCRT: endosomal sorting complex required for transport; FBXO27: F-box protein 27; iPSC-NDs: induced pluripotent stem cell-derived neuronal differentiated cells; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile alpha motif containing 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; p-MAPT/tau: phosphorylated microtubule associated protein tau; ROS: reactive oxygen species; STZ: streptozotocin; TFE3: transcription factor E3; TFEB: transcription factor EB; TRIM16: tripartite motif containing 16; UBE2QL1: ubiquitin conjugating enzyme E2 Q family like 1; VCP: valosin containing protein.

SUBMITTER: Chae CW

PROVIDER: S-EPMC10472864 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

Chae Chang Woo CW Yoon Jee Hyeon JH Lim Jae Ryong JR Park Ji Yong JY Cho Ji Hyeon JH Jung Young Hyun YH Choi Gee Euhn GE Lee Hyun Jik HJ Han Ho Jae HJ

Autophagy 20230704 10

<h4>Abbreviations</h4>Aβ: amyloid β; AD: Alzheimer disease; AMPK: 5' adenosine monophosphate-activated protein kinase; CTSB: cathepsin B; CTSD: cathepsin D; DM: diabetes mellitus; ESCRT: endosomal sorting complex required for transport; FBXO27: F-box protein 27; iPSC-NDs: induced pluripotent stem cell-derived neuronal differentiated cells; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile alpha motif containing 1; MA ...[more]

PMID: 37357416

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TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

Abbreviations

Publications

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.

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