Investigation and evaluation of a 3D‐printed optical modified cultivation vessel for improved scattered light measurement of biotechnologically relevant organisms

ABSTRACT: Abstract In the field of bioprocess development miniaturization, parallelization and flexibility play a key role reducing costs and time. To precisely meet these requirements, additive manufacturing (3D‐printing) is an ideal technology. 3D‐printing enables rapid prototyping and cost‐effective fabrication of individually designed devices with complex geometries on demand. For successful bioprocess development, monitoring of process‐relevant parameters, such as pH, dissolved oxygen (DO), and biomass, is crucial. Online monitoring is preferred as offline sampling is time‐consuming and leads to loss of information. In this study, 3D‐printed cultivation vessels with optical prisms are evaluated for the use in upstream processes of different industrially relevant microorganisms and cell lines. I

SUBMITTER: Rehfeld J 

PROVIDER: S-EPMC10472911 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature