Distinct neurophysiology during nonword repetition in logopenic and non-fluent variants of primary progressive aphasia.

ABSTRACT: Overlapping clinical presentations in primary progressive aphasia (PPA) variants present challenges for diagnosis and understanding pathophysiology, particularly in the early stages of the disease when behavioral (speech) symptoms are not clearly evident. Divergent atrophy patterns (temporoparietal degeneration in logopenic variant lvPPA, frontal degeneration in nonfluent variant nfvPPA) can partially account for differential speech production errors in the two groups in the later stages of the disease. While the existing dogma states that neurodegeneration is the root cause of compromised behavior and cortical activity in PPA, the extent to which neurophysiological signatures of speech dysfunction manifest independent of their divergent atrophy patterns remain unknown. We test the hypothe

SUBMITTER: Hinkley LBN 

PROVIDER: S-EPMC10472914 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature