Pharmacokinetics and tolerability of multiple-day oral dosing of mycophenolate mofetil in healthy horses.

ABSTRACT:

Background

Additional efficacious immunomodulatory treatment is needed for the management of immune-mediated disease in horses. Mycophenolate mofetil (MMF) is an immunosuppressive drug that warrants assessment as a viable therapeutic agent for horses.

Hypothesis/objectives

To evaluate the pharmacokinetics (PK) of multiple-day oral dosing of MMF in healthy horses and to determine the tolerability of this dosing regimen.

Animals

Six healthy Standardbred mares.

Methods

Horses received MMF 10 mg/kg PO q12h for 7 days in the fed state. Serial sampling was performed over 12 hours on Days 1 and 7 with trough samples collected every 24 hours, immediately before morning drug administration. Noncompartmental PK analyses were performed to determine primary PK parameters,

SUBMITTER: Bello K 

PROVIDER: S-EPMC10472989 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature