The effects of orally administered trazodone on ambulation and recumbency in healthy horses.

ABSTRACT:

Background

Trazodone, a serotonin receptor antagonist and reuptake inhibitor, might be a useful adjunctive treatment in the initial management of horses with acute laminitis if it minimizes ambulation or encourages recumbency.

Objectives

(1) Evaluate the effects of PO trazodone on ambulatory activity and recumbency in healthy horses; and (2) assess the pharmacokinetics of multiple PO doses of trazodone.

Animals/methods

In a randomized cross-over design, 8 healthy horses received placebo or trazodone at 2 doses (2.5 and 7.5 mg/kg) PO q12h for 48 hours with a 14-day washout period between treatments. Forelimb step frequency was measured using a hoof-mounted accelerometer and continuous video monitoring was used to detect recumbency. Groups were compared using repeated m

SUBMITTER: Hobbs K 

PROVIDER: S-EPMC10472990 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature