Association of serum and fecal microRNA profiles in cats with gastrointestinal cancer and chronic inflammatory enteropathy.

ABSTRACT:

Background

Differentiation of gastrointestinal cancer (GIC) from chronic inflammatory enteropathies (CIE) in cats can be challenging and often requires extensive diagnostic testing. MicroRNAs (miRNAs) have promise as non-invasive biomarkers in serum and feces for diagnosis of GIC.

Hypothesis/objectives

Cats with GIC will have serum and fecal miRNA profiles that differ significantly from healthy cats and cats with CIE. Identify serum and fecal miRNAs with diagnostic potential for differentiation between cats with GIC and CIE as compared to healthy cats.

Animals

Ten healthy cats, 9 cats with CIE, and 10 cats with GIC; all client-owned.

Methods

Cats were recruited for an international multicenter observational prospective case-control study. Serum and feces were s

SUBMITTER: Brogaard L 

PROVIDER: S-EPMC10473000 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature