Effects of S-Adenosylmethionine on Cognition in Animals and Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

There is increasing evidence that supplementation of S-adenosylmethionine (SAM) can improve cognitive function in animals and humans, although the outcomes are not always inconsistent.

Objective

We conducted a systematic review and meta-analysis to evaluate the correlation between SAM supplementation and improved cognitive function.

Methods

We searched studies in the PubMed, Cochrane Library, Embase, Web of Science, and Clinical Trials databases from January 1, 2002 to January 1, 2022. Risk of bias was assessed using the Cochrane risk of bias 2.0 (human studies) and the Systematic Review Center for Laboratory Animal Experimentation risk of bias (animal studies) tools; and evidence quality was evaluated using the Grading of Recommendations Assessment, Develo

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10473070 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature