Parkinson's Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research.

ABSTRACT:

Background

Large prospective studies are essential for investigating the environmental causes of Parkinson's disease (PD), but PD diagnosis via clinical exams is often infeasible in such studies.

Objective

To present case ascertainment strategy and data collection in a US cohort of women.

Methods

In the Sister Study (n = 50,884, baseline ages 55.6±9.0), physician-made PD diagnoses were first reported by participants or their proxies. Cohort-wide follow-up surveys collected data on subsequent diagnoses, medication usage and PD-relevant motor and nonmotor symptoms. We contacted self-reported PD cases and their treating physicians to obtain relevant diagnostic and treatment history. Diagnostic adjudication was made via expert review of all available data, except nonmotor

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10473078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature