Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson's Disease: Longitudinal Data from the PPMI Study.

ABSTRACT:

Background

The role of blood uric acid as a biomarker in symptomatic motor PD has been increasingly established in the literature.

Objective

Our present study assessed the role of serum uric acid as a putative biomarker in a prodromal PD cohort [REM Sleep Behavior disorder (RBD) and Hyposmia] followed longitudinally.

Methods

Longitudinal 5-year serum uric acid measurement data of 39 RBD patients and 26 Hyposmia patients with an abnormal DATSCAN imaging were downloaded from the Parkinson's Progression Markers Initiative database. These cohorts were compared with 423 de novo PD patients and 196 healthy controls enrolled in the same study.

Results

After adjusting for age, sex, body mass index, and concomitant disorders (hypertension/gout), baseline and longitudina

SUBMITTER: Koros C 

PROVIDER: S-EPMC10473106 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature