Sleep Dysregulation Is Associated with ¹⁸F-FDG PET and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease.

ABSTRACT:

Background

Sleep impairment has been commonly reported in Alzheimer's disease (AD) patients. The association between sleep dysregulation and AD biomarkers has been separately explored in mild cognitive impairment (MCI) and AD patients.

Objective

The present study investigated cerebrospinal-fluid (CSF) and ¹⁸F-fluoro-deoxy-glucose positron emission tomography (¹⁸F-FDG-PET) biomarkers in MCI and AD patients in order to explore their association with sleep parameters measured with polysomnography (PSG).

Methods

MCI and AD patients underwent PSG, ¹⁸F-FDG-PET, and CSF analysis for detecting and correlating these biomarkers with sleep architecture.

Results

Thirty-five patients were included in the study (9 MCI and 26 AD patients).

SUBMITTER: Fernandes M 

PROVIDER: S-EPMC10473116 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature