Acupuncture Therapy on Dementia: Explained with an Integrated Analysis on Therapeutic Targets and Associated Mechanisms.

ABSTRACT:

Background

Dementia, mainly Alzheimer's disease (AD) and vascular dementia (VaD), remains a global health challenge. Previous studies have demonstrated the benefits of acupuncture therapy (AT) in improving dementia. Nevertheless, the therapeutic targets and integrated biological mechanisms involved remain ambiguous.

Objective

To identify therapeutic targets and biological mechanisms of AT in treating dementia by integrated analysis strategy.

Methods

By the identification of differentially expressed genes (DEGs) of AD, VaD, and molecular targets of AT active components, the acupuncture therapeutic targets associated with the biological response to AD and VaD were extracted. Therapeutic targets-based functional enrichment analysis was conducted, and multiple networks we

SUBMITTER: Li D 

PROVIDER: S-EPMC10473135 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature