The Role of Interferon-α in Neurodegenerative Diseases: A Systematic Review.

ABSTRACT:

Background

Neurodegenerative diseases (NDs) impose significant financial and healthcare burden on populations all over the world. The prevalence and incidence of NDs have been observed to increase dramatically with age. Hence, the number of reported cases is projected to increase in the future, as life spans continues to rise. Despite this, there is limited effective treatment against most NDs. Interferons (IFNs), a family of cytokines, have been suggested as a promising therapeutic target for NDs, particularly IFN-α, which governs various pathological pathways in different NDs.

Objective

This systematic review aimed to critically appraise the currently available literature on the pathological role of IFN-α in neurodegeneration/NDs.

Methods

Three databases, Scopus, Pu

SUBMITTER: Hui BSM 

PROVIDER: S-EPMC10473139 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature