The pattern of MHC class I expression in muscle biopsies from patients with myositis and other neuromuscular disorders.

ABSTRACT:

Objective

Diagnostic muscle biopsies are routinely immunostained for major histocompatibility complex class I (MHC-I) protein. In this study we analysed the prevalence and patterns of MHC-I immunostaining in biopsies from patients with different types of myopathies and neurogenic disorders.

Methods

All 357 diagnostic muscle biopsies processed at the Johns Hopkins Neuromuscular Pathology Laboratory from August 2013 to January 2017 were immunostained for MHC-I. The prevalence and patterns of MHC-I immunostaining were compared between patients with histologically normal muscle biopsies (n = 31), idiopathic inflammatory myopathies (IIMs; n = 170), non-inflammatory myopathies (n = 60) and neurogenic disorders (n = 96).

Results

MHC-I immunostaining was abnormal in most pati

SUBMITTER: Milisenda JC 

PROVIDER: S-EPMC10473215 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature