Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease.

ABSTRACT:

Objectives

To explore the course of lung function and RA disease activity and predictive factors for deteriorating lung function in patients with RA-interstitial lung disease (ILD).

Methods

The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients with RA-ILD were enrolled and followed up annually for 3 years for RA disease activity and ILD status assessment. Group-based modelling was used to cluster a similar predicted percentage of forced vital capacity (FVC%) patterns into trajectories.

Results

This study included 140 patients who underwent at least two pulmonary function tests. Four distinctive trajectories for predicted FVC% were 'improving' [n = 11 (7.9%)], 'stable' [n = 68 (38.4%)], 'slowly dec

SUBMITTER: Chang SH 

PROVIDER: S-EPMC10473227 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature