Prediction of damage trajectories in systemic sclerosis using group-based trajectory modelling.

ABSTRACT:

Objectives

Damage accrual in SSc can be tracked using the Scleroderma Clinical Trials Consortium Damage Index (DI). Our goal was to develop a prediction model for damage accrual in SSc patients with early disease.

Methods

Using patients with <2 years disease duration from Canada and Australia as a derivation cohort, and from the Netherlands as a validation cohort, we used group-based trajectory modelling (GBTM) to determine 'good' and 'bad' latent damage trajectories. We developed a prediction model from this analysis and applied it to patients from derivation and validation cohorts. We plotted the actual DI trajectories of the patients predicted to be in 'good' or 'bad' groups.

Results

We found that the actual trajectories of damage accumulation for lcSSc and dcSSc w

SUBMITTER: Baron M 

PROVIDER: S-EPMC10473274 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature